MicroRNAs在胃肠道疾病发生中的调控作用及其机制

Regulatory role and mechanism of MicroRNAs in pathophysiology of gastrointestinal diseases

MicroRNAs(miRNAs)是一类广泛存在于动、植物中的内源性非编码小RNA,通过影响mRNAs的翻译或稳定性来发挥重要的调节作用。miRNAs的表达差异不仅可能与胃肠道肿瘤的发生、复发转移及预后有关,其在一些胃肠道良性疾病如萎缩性胃炎、溃疡性结肠炎及肠易激综合征等的发生机制中也可能起着重要的作用。

MicroRNAs（miRNAs） is a class of non-protein coding,endogenous small RNAs in animals and plants.They play important roles in regulating the expression of various mRNAs by directing mRNA degradation or repression the translation of target mRNA.The differential expression of miRNAs is not only associated with carcinogenesis,recurrence,metastasis and prognosis of gastrointestinal neoplasms,but also plays a key role in pathogenesis of many benign diseases,such as atrophic gastritis,ulcerative colitis,irritable bowel syndrome and so on.