期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

宿主免疫基因多态性与幽门螺杆菌感染相关疾病的关系 被引量：1

The relationship between host immunogene polymorphism and Helicobacter pylori related disease
下载PDF
导出
摘要 幽门螺杆菌(Helicobacter pylori,H.pylori)感染与消化性溃疡、萎缩性胃炎、胃MALT(Mucosa-associated lymphoid tissue)淋巴瘤及胃癌等疾病的发生密切相关。H.pylori感染引起的不同临床结局主要与H.pylori致病因子、宿主因素和环境因素三方面有关。目前宿主基因易感性的差异在H.pylori感染致病的作用已成为研究热点,本文就宿主免疫基因的多态性与幽门螺杆菌感染所致疾病关系的研究进行总结,从宿主TOLL样受体、NOD受体、CD14及HLA等免疫因子基因多态性进行综述。 H.pylori infection may cause many gastroentestinal diseases,such as peptic ulcers,chronic atrophic gastritis,MALT（Mucosa-associated lymphoid tissue） lymphoma and gastric cancer.The different clinical outcome of H.pylori infection is related to H.pylori virulence factors,host factor and environmental factor.The difference of host gene polymorphism may cause different outcome of the H.pylori infection.This review has summarized current researches about the effects of host immunogene polymorphism on gastric disease associated with H.pylori infection,including TLR,NOD,CD14 and HLA genetic polymorphism.
作者 郝雯颖 郭明洲 梁浩
机构地区 中国人民解放军总医院消化内科
出处 《胃肠病学和肝病学杂志》 CAS 2010年第4期309-312,共4页 Chinese Journal of Gastroenterology and Hepatology
关键词 幽门螺杆菌 宿主免疫基因多态性 H.pylori Host immunogene polymorphism
分类号 R573 [医药卫生—消化系统]
  • 相关文献

参考文献23

  • 1Ferlay J, Autier P, Boniol M, et al. Estimates of the cancer incidence and mortality in Europe in 2006 [ J]. Ann Oncol, 2007, 18 (3) : 581- 592.
  • 2Knapp S, Wieland CW, van' t Veer C, et al. Toll like receptor 2 plays a role in the early innammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense [ J]. J lmmunol,2004, 172(5): 3132-3138.
  • 3Gao B, Tsan MF. Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages [J]. J Biol Chem, 2003, 278(25): 22523-22529.
  • 4Hishida A, Matsuo K, Goto Y, et al. Toll-Like receptor 4 + 3725 G/ C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese [ J ]. Helieobaeter, 2009, 14(1) : 47-53.
  • 5Schmausser B, Andrulis M, Endrich S, et al. Expression and subcellular distribution of Toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection [ J]. Clin Exp Immunol, 2004, 136(3) : 521-526.
  • 6Hold GL, Rabkin CS, Chow WH, et al. A functional polymorphism of Toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors [ J]. Gastroenterology, 2007, 132 (3) : 905-912.
  • 7Achyut BR, Ghoshal UC, Moorchung N, etal. Association of Toll-like receptor-4 (Asp299Gly and Thr39911eu) gene polymorphisms with gastritis and precancerous lesions [ J ]. Hum Immunol, 2007, 68 ( 11 ) : 901-907.
  • 8Tahara T, Arisawa T, Shibata T, et al. Absence of common polymorphisms of Toll like receptor 4 (TLR4) : Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japan [J]. J Clin Biochem Nutr, 2007, 40(1) : 62-65.
  • 9Ture-Ozdemir F, Gazouli M, Tzivras M, et al. Association of polymorphisms of NOD2, TLR4 and CDI4 genes with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma [ J ]. Anticancer Res, 2008, 28(6A) : 3697-3700.
  • 10Hellmig S, Fischbaeh W, Goebeler-Kolve ME, et al. Association study of a functional Toll-like receptor 4 polymorphism with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma [ J]. Leuk Lymphoma, 2005, 46(6) : 869-872.

二级参考文献13

  • 1孙宁玲，中华医学遗传学杂志，1998年，15卷，288页
  • 2Lee J E，Gastroenterology，1996年，111卷，426页
  • 3Rigas B，Gastroenterology，1996年，111卷，523页
  • 4Morris A, Ali MR, Thomsen L, et al. Tightly spiral shaped bacteria in the human stomach: another cause of active chronic gastritis[J]. Gut, 1990, 31(2):139-143.
  • 5Harris PR, Mobley HL, Perez Perez GI, et al. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production [J]. Gastroenterology, 1996, 111(2):419-425.
  • 6Terres AM, Pajares JM. An increased number of follicles containing activated CD69+ helper T cells and proliferation CD71+ B cells are found in H.pylori-infected gastric mucosa[J]. Am J Gastroenterol, 1998, 93(4):579-583.
  • 7Ligumsky M, Simon PL, Karmeli F, et al. Role of interleukin 1 in inflammatory bowel disease-enhanced production during active disease [J]. Gut, 1990, 31(6):686-689.
  • 8Hirozane N, Tanaka K, Nakane Y, et al. Expression of HLA-DR and secretory component antigens and lymphocyte infiltration in human gastric nonmalignant and malignant tissues: an immunohistochemical study [J]. J Surg Oncol, 1991, 46(2):77-86.
  • 9Engstrand L, Scheynius A, Pahlson C, et al. Association of Campylobacter pylori with induced expression of class Ⅱ transplantation antigens on gastric epithelial cells [J]. Infect Immun, 1989, 57(3):827-832.
  • 10Wee A, Teh M, Kang JY. Association of Helicobacter pylori with HLA-DR antigen expression in gastritis[J]. J Clin Pathol, 1992, 45(1):30-33.

共引文献14

同被引文献3

引证文献1

二级引证文献3

胃肠病学和肝病学杂志
2010年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部