胃幽门螺杆菌感染与口腔异味感关系的相关性研究

Correlation between Helicobacter pylori infection and halitosis

目的探讨口腔异味感(俗称口臭)的病因与胃幽门螺杆菌感染的相关性。方法随机选择因上消化道症状就诊于我院消化科(无口腔疾病及全身疾病)的353例患者,首先进行口臭测试,根据有无口臭分为口臭组和无口臭组,所有病例均行13C呼气试验,观察各组中幽门螺杆菌感染率。同时根据有无幽门螺杆菌感染分为感染组和无感染组,观察口臭的发生率。结果353例患者中,口臭组166例,占47.03%,其中胃幽门螺杆菌阳性109例(65.66%);无口臭组187例,占52.97%,其中胃幽门螺杆菌阳性68例(36.36%);两组间差异有统计学意义(χ2=30.19,P<0.001),口臭与幽门螺杆菌感染两者间相关系数r=0.29。幽门螺杆菌感染阳性177例,感染率为50.14%,其中口臭134例,占75.71%;幽门螺杆菌检测阴性176例,其中口臭32例,占18.19%;两组间差异有统计学意义(χ2=117.22,P<0.001),幽门螺杆菌感染与口臭发生率两者间相关系数r=0.58。结论口臭的病因可能与胃幽门螺杆菌感染有较大的相关性,胃幽门螺杆菌感染有可能是导致口臭的一个原因。

Objective To investigate the correlation between halitosis and H.pylori infection.Methods Three hundred and fifty-three cases with upper gastrointestinal symptoms in our hospital gastroenterology（without periodontal diseases and systematic disease in all cases） were selected randomly.13C-urea breath test（^13C-UBT） was taken firstly.The H.pylori infection rates were observed in each group.At the same time,according to whether infected with H.pylori infection,these cases were divided into infected group and non-infected group.The Halitosis was observed in each group.Results In 353 cases,there were 166 cases with halitosis（47.03%）,in which,109 cases were positive（65.66%） in H.pylori detection;there were 187 cases without halitosis（52.97%）,in which,68 cases were positive（36.36%） in H.pylori detection.The difference between two groups was statistically significant（χ^2=30.19,P〈0.001,r=0.29）.In 353 cases,there were 177 cases with positive in H.pylori detection（50.14%）,in which,134 cases had halitosis（75.71%）;176 cases were negative in H.pylori detection,in which,32 cases had halitosis（18.19%）.The difference between two groups was statistically significant（χ^2=117.22,P〈0.001,r=0.58）.Conclusion There is a significantly positive probability of correlation between H.pylori infection and halitosis,H.pylori infection is one of the reasons of halitosis.