p-mTOR、GST-π和Ki-67在食管鳞状细胞癌中的表达及其相关性

Expression of p-mTOR,GST-π and Ki-67 in Human Esophageal Squamous Cell Carcinomas and Their Correlations

目的研究p-mTOR、GST-π、Ki-67在食管鳞状细胞癌中的表达,并探讨三者表达水平的相关性和意义。方法运用免疫组织化学SP法检测88例不同分化程度的食管鳞状细胞中p-mTOR、GST-π和Ki-67的表达情况。结果p-mTOR、GST-π、Ki-67在食管高分化鳞癌中阳性表达率分别为20.8%、25%和62.5%,在中分化鳞癌中阳性表达率分别为39.1%、45.7%和65.4%,在低分化鳞癌中阳性表达率分别为66.7%、72.2%和94.4%。食管鳞癌组织中GST-π和p-mTOR表达水平具有相关性(rs=0.797,P<0.01),与Ki-67的表达水平则没有相关性(rs=0.126,P>0.05)。结论p-mTOR、GST-π和Ki-67的表达水平与食管鳞癌细胞的分化程度密切相关。GST-π表达水平与p-mTOR密切相关。p-mTOR阳性的食管鳞癌患者可能从p-mTOR活性抑制治疗中受益。

Objective To study the relationship of the expression of p-mTOR,GST-π and Ki-67 and their correlations in esophageal squamous cell carcinomas（ESCC）. Methods The expression of p-mTOR,GST-π and Ki-67 was detected by SP immunohistochemical staining in ESCC. Results The positive expression rates of p-mTOR,GST-π and Ki-67 were 20.8%,25%,62.5% in well-differentiated group, 39.1%,45.7%,65.4% in moderately differentiated group and 66.7%,72.2%,94.4% in poorly differentiated group respectively. Significant correlation was found between the expression of p-mTOR and GST-π in ESCC（rs=0.797,P〈0.01）, while no correlation was detected between p-mTOR and Ki-67（rs=0.126,P〉0.05）. Conclusion The expressions of p-mTOR, GST-π and Ki-67 correlate significantly with ESCC differentiation.The expression level of GST-π correlates with p-mTOR significantly.Thus the subset of patients with p-mTOR positive may potentially benefit from p-mTOR inhibiting therapy.