OPN和VEGF的表达在乳腺癌复发转移中的意义

Significance of OPN and VEGF Expression in Recurrent and Metastatic Breast Cancer

目的探讨乳腺癌组织中OPN的表达及其与VEGF的联合表达对乳腺癌复发转移的影响以及在乳腺癌中两者的相互关系。方法选取中南大学湘雅医院乳腺科1996～2001年间手术,并获随访的乳腺癌患者70例,分为5年内复发转移组40例(A组)和无瘤生存5年以上组30例(B组),纤维瘤组织10例(C组)及正常乳腺组织15例(D组)。应用免疫组化法检测OPN、VEGF的表达情况。结果(1)OPN在70例乳腺癌组织中阳性表达率为72.86%,与C组及D组的OPN表达比较差异有统计学意义(P<0.001);(2)OPN和乳腺癌的复发转移有关;A、B组间OPN表达及它与VEGF的联合表达经χ2检验及Log-rank检验差异均存在统计学意义;(3)OPN与VEGF正相关(P<0.05),r=0.421。结论OPN可能与乳腺癌的发生发展及预后有关。在乳腺癌中它与VEGF的表达正相关。两者高表达患者易发生复发转移。

Objective To study the expression of OPN and VEGF in breast cancer and to explore the effect of OPN and their unions recurrent and metastatic breast cancer. Methods Forty cases with recurrence or metastasis in 5 years （group A）,30 cases without recurrence or metastasis in 5 years （group B）,and 10 cases with breast fibroid tumor（group C）and 15 cases normal breast tissue （group D）, surgically resected in the department of breast surgery, Xiang ya hospital, from 1996 to 2001, were included in this study. The expressions of OPN and VEGF were studied in four groups with immunohistochemical staining technique.Results （1）The positive expression rate of OPN in breast cancer was 72.86%,which was different from group C and group D （P〈0.001）.（2）The expressions of OPN and their unions were statistically significant different between group A and B.（3）The expression of OPN and VEGF was direct correlation （P〈0.05,r=0.421）.Conclusion The positive expression rates of OPN may correlate with the development and prognosis of breast carcinoma. Its expression was positively correlated with VEGF. The patients with OPN and VEGF union expression had the worse prognosis.