尿激酶经导管溶栓治疗下肢深静脉血栓形成110例

Clinical research of catheter-directed thrombolysis for deep venous thrombosis of lower extremity

目的:探讨尿激酶在经导管溶栓治疗下肢深静脉血栓形成(DVT)中的应用。方法:使用经导管溶栓治疗DVT,并按尿激酶用量、给药频率将患者分组。结果:血栓溶解率小剂量组为(38.7±24.0)%,标准组为(54.8±26.0)%,大剂量组为(53.0±21.0)%,小剂量组与标准组差异有统计学意义(P<0.01)。当每日给药频率由2次增加至3次、4次时,血栓溶解率由(38.9±19.0)%分别上升至(49.3±20.0)%和(63.8±18.0)%,两两比较差异均有统计学意义(P≤0.05)。结论:尿激酶每日用量在30万U左右时,量效关系比较满意,增加尿激酶用量并不能明显提高血栓溶解率,增加每日尿激酶给药频率,可以提高血栓溶解率。

Objective： To study the application of urokinase in the catheter-directed thrombolysis （CDT）treatment of non-acute deep venous thrombosis （DVT）of lower extremity. Methods： Patients enrolled were treated with CDT,and divided inito different groups by different urokinase dose and frequency. Results： The thrombolytic rate was （38.7±24.0）in little dose group（,54.8±26.0）in normal group and（53.0±21.0）in big dose group. There was notable difference between the little and big dose group（P0.01）. The thrombolytic rate rised from（38.9±19.0）to（49.3±20.0）and 63.8±18.0）when the frequency rised from 2 to 3 and 4 per day,and there was notable difference between each groups （P≤0.05）. Conclusion： The effect of treatment is satisfied when the urokinase dose is about 300 000U per day,and the thrombolytic rate rised with the frequency of urokinase.