放射性农药标记化合物的合成研究进展

A REVIEW:RADIOLABELED SYNTHESIS OF PESTICIDES

放射性核素示踪技术在农药代谢降解、作用机理与环境行为等研究中得到了广泛应用。而利用放射性同位素标记示踪法研究农药的关键在于如何获得合适的农药标记化合物。放射性同位素农药标记化合物通常很难从国内外市场中直接获得,尤其是新的、结构较复杂的且合成路线较长的农药标记化合物。放射性农药标记化合物的合成对合成产率要求较常规有机合成高,合成路线也往往不同于非放射性农药合成。本文对放射性同位素标记农药的合成中如何选择放射性核素及正确的标记位置、主要的合成方法、合成过程中需要注意的问题等进行了综述。

Isotope tracer technique has been widely applied in studies of metabolism,mode action,fate and environmental behavior of pesticides.In such studies,the key point is to obtain suitable radiolabelled compounds.However,the radiotracers,especially the labelled pesticides which are novel compounds with complex structures and longer synthesis routes,are usually unavailable from domestic and /or foreign markets.Therefore,it is essential to explore the synthesis methods of radiolabelled pesticides,which are quite different from the conventional nonradiosynthesis,and are requested to obtain higher yield.This article is a review on current status of choosing the available radionuclide and labelled position,the main synthesis methods and problems in the process of preparing radiolabelled pesticides.