垂体腺瘤p53蛋白表达及其意义

p53 expression in pituitary adenomas and its significance

目的：研究突变型ｐ５３癌基因在垂体腺瘤中的表达。方法：应用免疫组化ＡＢＣ法检测６４例垂体腺瘤（复发组３１例，非复发组３３例），６例正常垂体、２例垂体癌中ｐ５３蛋白表达情况。结果：复发组中有１０例ｐ５３蛋白表达阳性，非复发组中有２例ｐ５３蛋白表达阳性，两组差异有显著性。２例垂体癌ｐ５３蛋白强阳性表达，６例正常垂体无阳性表达。ｐ５３蛋白在不同激素类型垂体腺瘤中的阳性表达率差异无显著性。结论：ｐ５３蛋白高表达与少数垂体腺瘤的潜在恶性及复发有关，与垂体腺瘤激素类型无关。

Purpose To study the expression of mutant p53 in pituitary adenomas. Methods ABC immunohistochemical study of p53 was carried out on paraffinembedded sections of 64 pituitary adenomas (31 recurrent, 33 nonrecurrent), 6 normal pituitary gland tissues and 2 pituitary adenocarcinomas. Results p53 protein accumulation was detected in 10 of 31 cases of recurrent pituitary adenomas, 2 of the 33 cases of nonrecurrent pituitary adenomas and 2 cases of pituitary adenocarcinomas. No p53 protein accumulation was identified in 6 normal pituitary gland tissues. Protein accumulation was significantly differences between the recurrent group and nonrecurrent group, but was no significantly differences among various types of hormone of pituitary adenomas. Conclusions p53 positive expression indicates the potent malignence and recurrence of pituitary adenomas, but it isnt connected with the type of hormone of the pituitary adenomas.