白细胞介素-4基因多态性与非小细胞肺癌易感性研究

The Relationship between Interluekin-4 Gene Polymorphism and Susceptibility to Non-small Cell Lung Cancer

目的探讨白细胞介素（interluekin，IL）-4基因多态性与非小细胞肺癌易感性的关系。方法采用PIRA-PCR分析的方法检测了235例非小细胞肺癌患者和216名正常对照者的IL-4T-168C（rs2070874）多态性，分析其基因型与非小细胞肺癌发病风险的相关性。结果在非小细胞肺癌患者中，TC基因型出现的频率（28．9％）明显低于正常对照组（37．5％）。TC基因型显著降低了非小细胞肺癌的易感性（OR=0．65．95％CI=O．47～0．97；P=O．04）；非小细胞肺癌患者中携带c型等位基因的基因型（TC／CC）频率明显低于正常对照组中相应基因型的频率（64．3％VS73．5％；OR=o．64，95％CI=0．48---0．96；P=O．03）。结论IL．4T-168C（rs2070874）多态性可能与中国人群非小细胞肺癌的遗传易感性相关。

Objective To investigate whether the polymorphisms ofinterleukin （IL）-4 contribute to susceptibil- ity of non-small cell lung cancer in Chinese population.Methods The PIRA-PCR technique was applied to analysis the IL-4 T-168C （rs2070874） polymorphism in 235 non-small cell lung cancer patients and in 216 healthy controls. The association of different genotypes and non-small cell lung cancer risk was calculated by regression analysis. Results The frequency of the TC genotype was significantly decreased in non-small cell lung cancer group（28.9%） than that in healthy controls （37.5%）,indicating that TC genotype decreased the risk of non-small cell lung cancer （OR=0.65, 95% CI =0.47-0.97;P=0.04）. Furthermore, the frequency of individuals who carrying the C allele （TC/ CC genotypes） was remarkably decreased in non-small cell lung cancer patients when compared with healthy controls （64.3% vs 73.5%;OR =0.64, 95% CI =0.48-0.96;P=0.03）.Coneiusion Our results indicate that IL-4 T- 168C （rs2070874） may be associated with genetic susceptibility to non-small cell lung cancer in Chinese population.