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RELMα对动脉粥样硬化清道夫受体表达的影响

The Effect of RELM α on the Expression of VSMCs SR-A and Macrophages CD36
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摘要 目的探讨抵抗素样分子α（RELMα）对与动脉粥样硬化密切相关的巨噬细胞清道夫受体CD36以及平滑肌细胞清道夫受体A（SR-A）表达的影响。方法体外培养巨噬细胞以及平滑肌细胞，用氧化低密度脂蛋白（ox-LDL）I）2及终浓度分别为3 × 10^-6mmol／L，9 × 10^-6mmol/L，2．7 × 10^-5mmol／L的RELMα刺激培养的细胞，24h后收集细胞，用流式细胞仪测定巨噬细胞清道夫受体CD36以及平滑肌细胞SR．A表达。结果OX．LDL明显促进巨噬细胞CD36表达，重组RELMα不影响OX-LDL诱导的体外培养的巨噬细胞清道夫受体CD36的表达，重组RELMα能明显促进OX．LDL诱导的平滑肌细胞SR-A表达（与对照组比较，P〈0．01）。结论RELMa不影响OX．LDL诱导的巨噬细胞清道夫受体CD36的表达，但能促进OX．LDL诱导的平滑肌细胞SR-A表达，提示RELMα可能通过促进SR．A表达从而促进动脉粥样硬化进展。 Objective To explore the effect ofRELM α on VSMCs SR-A and macrophages CD36,which associated with atherosclerosis.Metbods Smooth muscle cells and macrophages were treated with ox-LDL（20mg/ L） plus recombinate RELM α at different concentration （final concentration 3 × 10-6mmol/L,9 × 10^6mmol/L,2.7 × 10-5mmol/L）.The expression of SR-A of smooth muscle cell and CD36 of macrophages was detected by flow cytometry.Results RELM α had no effect on the expression of scavenger receptor CD36 in cultured macrophages, which reveals that it couldn＇t interfere with the ox-LDL uptake of macrophages.RELM α enhanced the expression of SR-A of VSMC induced by ox-LDL （ RELM α groups vs control group,P〈0.01 ）.Conclusions RELM α enhanced the expression of SR-A of VSMC induced by ox-LDL,which indicates the involvement of RELM α in the development of atherosclerosis. K
作者 赵素华 张红明
机构地区 湖北省黄石市中心医院 济南军区总医院心内科
出处 《中国血液流变学杂志》 CAS 2010年第1期37-39,79,共4页 Chinese Journal of Hemorheology
关键词 动脉粥样硬化 RELMα 清道夫受体A Atherosclerosis RELM α Scavenger receptor A
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献9

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中国血液流变学杂志
2010年 第1期

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