血尿酸联合纤维蛋白原对慢性阻塞性肺疾病急性加重期预后评估价值

The Predictive Values of Serum Uric Acid and Plasma Fibrinogen in Patients with Acute Exacerbation of Severe Chronic Obstructive Pulmonary Disease

目的探讨血尿酸（UA）和纤维蛋白原（FIB）在慢性阻塞性肺疾病急性加重期（AECOPD）预后评估价值。方法AECOPD组81例，经2周治疗后分为好转组（65例）及未好转组（16例），检测治疗前后血uA和FIB变化；健康对照组70名，检测血UA和FIB值作为对照。结果AECOPD患者治疗前血uA和FIB浓度明显高于健康对照组（P〈0．01）。好转组治疗后uA和FIB较治疗前显著降低（P〈0．05），未好转组UA和FIB治疗前后比较，差异无统计学意义（P〉0．05）。结论UA联合FIB可能可作为AECOPD患者评估严重程度及预后的标志物和预测因子。

Objective To evaluate the values of serum uric acid（UA） and plasma fibrinogen（FIB） as a marker or predictor for patients with acute exacerbation of severe chronic obstructive pulmonary disease（AECOPD）. Methods Two weeks before and after the therapy,the levels of serum UA and plasma FIB were measured among 81 cases with AECOPD（AECOPD group）,and 70 cases of health elderly individuals （control group）. According to the outcome of therapy,AECOPD group were divided into improved group（n=65） and unimproved group（n=l 6）. Results The levels of serum UA and plasma FIB of AECOPD group were higher those of the control group（P〈 0.01） before therapy. After the therapy for two weeks,the levels of serum UA and plasma FIB decreased signifi- cantly in the improved group, but not in the unimproved group.Conclusion The serum UA and plasma FIB could be used as a marker or predictor for the development of AECOPD.