^(32)磷玻璃微球间质治疗对肿瘤微血管作用的实验研究

The Effect of Internal Irradiotherapy with 32 P Glass Microspheres on Tumor Vasculature in Mouse Sarcoma 180

为了探讨间质治疗对肿瘤微血管的影响，作者观察了移植性小鼠Ｓ１８０实体瘤在３２磷玻璃微球间质治疗后的血管铸型及墨汁灌注切片。结果表明：治疗后肿瘤毛细血管数量减少，排列不规则，血管扩张；瘤周血管密度下降。提示间质治疗同外照射一样对肿瘤微血管有损伤作用。

In order to investigate the effect of internal irradiotherapy on tumor microvasculature,the vascular changes of tumor S180 following internal irradiotherapy with 32 P glass microspheres were observed microscopically with vessel casts of resin perfusion and ink perfusion. The results showed that the microvessels expanded with the endothelial cells swelling and the amount of microvessels and new vessels decreased,which led to peritumoral vascular density descended. It suggests that internal irradiotherapy destroying the tumor microvasculature as external irradiation is an important influeuce on the efficiency of internal irradiotherapy.