食管癌中癌基因产物c-fos、c-jun的表达

Expression of cfos, cjun oncogene products in esophageal carcinoma

目的：探讨癌基因ｃ－ｆｏｓ、ｃ－ｊｕｎ表达产物与食管癌的发生、发展及预后的关系。方法：应用免疫组织化学ＳＡＢＣ法，以兔抗ｃ－ｆｏｓ、ｃ－ｊｕｎ抗体标记６０例食管癌和１０例远端切缘粘膜。观察其在切缘食管粘膜、癌旁粘膜及不同分化程度和组织学类型食管癌的表达，并比较其阳性率。结果：ｃ－ｆｏｓ、ｃ－ｊｕｎ阳性反应见于癌旁粘膜和食管癌组织，癌旁粘膜ｃ－ｆｏｓ、ｃ－ｊｕｎ阳性率分别为７２．２％和５８．３％，癌组织为５５．０％和４８．３％；在食管癌表达的阳性率与癌组织分化程度和组织学类型有关（Ｐ＜０．０５），与淋巴结转移无关（Ｐ＞０．０５）。结论：提示ｃ－ｆｏｓ、ｃ－ｊｕｎ的过量表达可发生在不典型增生的食管粘膜和食管癌组织。

Purpose To determine the expression of cfos, cjun products in esophageal carcinoma (EC) and its relationship with the development and prognosis of the tumor. Methods Sixty cases of EC and 10 cases of distant mucosa were immunohistochemically stained for cfos, cjun. The positivity rates in different grades and different type of EC, paraEC and normal esophageal mucosa were compared statistically. Results cfos, cjun immunoreactivity was found in EC and paraEC. The positivity rates in paraEC were 722% (cfos) and 583% (cjun), and in EC, 550% (cfos) and 483% (cjun). In EC, the positive rates were related to different differentiation and histologic type (P<005), and were not related to lymph node matastasis of the tumors (P>005). Conclusions The results suggest that overexpression of cfos, cjun could occur in dysplasia esophageal mucosa and cancer tissue.