血管内血栓的介入性局部溶栓治疗

Interventional thrombolysis for treatment of intravascular thrombus

目的探讨血管内血栓的介入性局部溶栓治疗效果和临床应用中的有关问题。方法对１８例血管阻塞性病变进行渐进性脉冲－喷射血管内局部溶栓治疗，尿激酶１００００Ｕ／ＭＬ，剂量１００００Ｕ／分钟，总量３０～８０万Ｕ，平均３８万Ｕ。结果阻塞血管完全开通１４例（７７．８％），部分开通２例（１１．１％），无效２例（１１．１％）。平均溶栓时间２．８小时。结论血管内血栓的介入性局部溶栓治疗效果显著。

Objective To evaluate the interventional thrombolysis for treatment of untravascular thrombus and disscus the problems of its clinical use. Methods 18 patients with intravascular occlusive disease were treated with pulsed spray thrombolysis(PST).The concentration of urokinase was 10000U/ml.The dose of urokinase was 10000U/min,the total dose was from 300000U to 800000U,and the average dose was 380000U.Results In 18 cases,14 were obtained thrombolysis completely(77 8%),the cases of thrombolysis partly and unaffected were 2(11 1%)and 2(11 1%)in number respectively.The mean time of thrombolysis was 2 8 hours. Conclusion The treatment of thrombolysis is highly beneficial to the patients with intravascular occlusive disease.