参附注射液对肺挫伤患者血浆肿瘤坏死因子及白细胞介素的影响

Effect of shenfu injection on TNF, IL-6 , IL-8 in patients with pulmonary contusion

目的通过分析参附注射液对肺挫伤患者治疗前后血浆肿瘤坏死因子（TNF）、白细胞介素（IL-6、IL-8）水平变化，探讨其对肺挫伤的治疗效果。方法选择肺挫伤患者110例，随机分组。对照组行常规治疗，治疗组在常规治疗基础上加用参附注射液。检测治疗前后患者血浆TNF、IL-6、IL-8水平。结果治疗前两组患者肺挫伤评分差异无统计学意义（P〉0．05）；治疗后治疗组TNF、IL-6、IL-8水平明显降低，与对照组差异有统计学意义（P〈0．05）。结论参附注射液对肺挫伤具有治疗作用，可降低血TNF、IL-6、IL-8水平，减轻TNF、IL-6、IL-8所造成的继发性肺损伤、促进损伤组织的修复和肺功能的恢复。

Objective To Observe the levels of TNF, IL-6,IL-8 in patients with pulmonary contusion before and after treatment,explore its effect on the treatment of pulmonary contusion. Methods 110 pulmonary contusion patients were selected from wendeng central hospital thoracic surgical ward, 110 patients were randomly divided into treatment group and control group. The control group received routine treatment, the treatment group on the basis of conventional therapy was added Shenfu injection. The levels of TNF, IL-6, IL-8 from patients were tested. Results The two groups score showed no significant difference before treatment （ P 〉 0. 05 ）. Plasma TNF, IL-6, IL-8 levels in the treatnent group significantly reduced compared with control group after treatment （P 〈 0.05）. Conclusion Shenfu injection has therapeutic effect on pulmonary contusion, itcan reduce TNF, IL-6, IL-8 levels, antagonize TNF, IL-6, IL- 8 of the vasoconstrictive effect, thereby reducing TNF, IL-6, IL - 8 caused secondary lung injury, promote the repair of damaged tissue and lung function recovery.