4Kingsley LA,Fournier PG,Chirgwin JM,et al.Molecular biology of bone metastasis [J].Mol Cancer Ther,2007,6(10): 2609-2617.
5Kinder M,Chislock E,Bussard KM,et al.Metastatic breast cancer induces an osteoblast inflammatory response[J].Exp Cell Res,2008,314(1 ) : 173-183.
6Gregory RM.Metastasis: Metastasis to bone:causes,consequences and therapeutic opportunities [J].Nature Reviews Cancer,2006, 584-593.
7Hofbauer LC,Khosla S,Dunstan CR,et al.The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption [J].J Bone Miner Res,2000,15 (1):2-12.
9Kitazawa S,Kitazawa R.RANK ligand is a prerequisite for cancer-associated osteolytic lesions [J].J Pathol,2002,198: 228-236.
10Shen X,Qian L,Falzon M.PTH-related protein enhances MCF-7 breast cancer cell adhesion,migration,and invasion via an intracrine pathway [J].Exp Cell Res,2004,294(2): 420-433.
4Sills GJ.The mechanisms of action of gabapentin and pregabalin[J].Curr Opin Pharmacol,2006,6(1):108-113.
5Dworkin RH,O' Connor AB,Audette J,et al.Recommendationsfor the pharmacological management of neuropathic pain:an over-view and literature update [J].Mayo Clin Proc,2010,85 (3 Suppl):S3-14.
6Honore P,Rogers SD,Schwei MJ,et al.Murine models of inflam-matory ,neuropathic and cancer pain each generates a unique setof neurochemical changes in the spinal cord and sensory neurons[J].Neuroscience,2000,98(3) ;585-598.
7Yamamoto J,Kawamata T,Niiyama Y,et al.Down-regulation ofmu opioid receptor expression within distinct subpopulations ofdorsal root ganglion neurons in a murine model of bone cancerpain[J].Neuroscience,2008,151(3): 843-853.
8Eckhardt K,Ammon S,Hofmann U,et al.Gabapentin enhancesthe analgesic effect of morphine in healthy volunteers [J].AnesthAnalg,2000,91(1):185-191.
9Durkin B,Page C,Glass P.Pregabalin for the treatment of post-surgical pain[J].Expert Opin Pharmacother,2010,11 (16):2751-2758.