引导性骨再生模型中皮质骨哈弗系统再建及其作用

Haversian remodeling in guided bone regeneration

目的观察研究引导性骨再生模型中皮质骨内哈弗系统再建及其作用。方法成年新西兰兔２４只，一侧造成桡骨的１０ｍｍ骨缺损，以硅胶管套于缺损两侧外骨膜外，分别于术后３天和１、２、３、４、６、１０、１２周将动物处死，标本行Ｘ线、非脱钙骨切片组织学观察。结果哈弗系统再建的组织学表现为哈弗系统中央管管腔扩大、管壁皮质骨溶解、管腔内出现大量的成骨细胞。皮质骨内哈弗系统再建与其周围骨修复的部位相对应；皮质骨内哈弗系统再建与骨修复进程相关；哈弗系统中央管腔内的成骨细胞与周围骨修复组织中的成骨细胞相联系。结论引导性骨再生模型中，皮质骨内的哈弗系统再建与骨修复过程密切相关。

Objective To study the relationship between Haversian remodeling and bone regeneration in guided bone regeneration(GBR). Method 10 mm long segmental defects were created in the diaphses of one radiius in 24 rabbits.The defect was covered with silicone membrane shaped as a tube.Rabbits were killed at the 3rd day, 1st,2nd,3rd,4th,6th,10th,12th weeks.Undecalcified section was prepared for histologic examination. Result Bone resorption was seen in Haversian canal,connection between osteocytes and osteoblasts in Haversian,and connection of osteoblasts in Haversian and in callus. The process of Haversian remodeling was involved in the process of bone regeneration,just like primary bone healing.The process of Haversian remodeling and regeneration was coupled in topography,time and size. Conclusion Bone repair is related to Haversian remodeling.