肝内血管增生在乙型肝炎纤维化中的作用

Effect of vascular proliferation on liver fibrosis in hepatitis B

目的：探讨肝血管增生在慢性乙型肝炎（ＣＨＢ）纤维化（Ｆｉ）中的作用。方法：用平滑肌特异性肌动蛋白（αＳＭＡ）对２４０例ＣＨＢ肝内血管增生作检测。结果：在血管增生较轻组，灶性纤维化占８９％，在较重组桥形纤维化占８４％（Ｐ＜０．００５）。在肝硬变（Ｃｉ）大结节型血管增生较轻占６０％，在小结节及局限型增生较重者分别为９０％及９３％（Ｐ＜０．０１）。增生的血管、纤维带及肝窦毛细血管化区αＳＭＡ示强阳性表达。

Objective:To study the effect of vascular proliferation on liver fibrosis in chronic hepatitis B(CHB).Methods:Intrahepatic vascular proliferation of 240 cases of CHB was determined with alphasmooth mucle actin(αSMA).Results:89% of patients with mild vascular proliferation showed to have fibrous tissues in focal distribution;whereas,84% with severe vascular proliferation showed to have bridgefibrous tissues(P<0.005).Mild vascular proliferation was found in 60% of the cases with macrocirrhosis;whereas severe vascular proliferation was found in 90% microand 93% of focal cirrhosis(P<0.01).αSMA was strongly expressed in the proliferating vessels,fibrous zones,and the sinusoidal capillary regions.Conclusions:Smooth fiber has an important effect on fibrosis and cirrhosis.