乙肝病毒基因型对武汉地区慢性乙型肝炎患者干扰素α-2b疗效的影响

Relationship between hepatitis B virus genotype and efficacy of interferon alpha-2b in Wuhan

目的:探讨武汉地区慢性乙型肝炎(CHB)患者HBV基因型对干扰素α-2b疗效的影响。方法:以患者年龄、性别、基线指标进行匹配,按照基因分型结果分组,比较干扰素治疗48周时的应答情况。结果:在治疗48周结束时,基因B型HBV感染的患者完全应答率和HBeAg阴转率分别为43.8%(28/64)和68.2%(15/22),显著高于C型患者的完全应答率[22.2%(10/45)]和HBeAg阴转率[28.6%(4/14)]。结论:CHB患者HBV的基因型可影响干扰素α-2b的治疗效果,基因B型在治疗48周时应答情况优于基因C型。

Objective：To investigate the relationship between hepatitis B virus（HBV） genotype and efficacy of interferon alpha-2b in Wuhan district.Methods：Patients were grouped according to HBV genotype and matched by age,gender and characteristics of baseline.Results：The complete response rate（43.8%,28/64） and rate of loss of HBeAg（68.2%,15/22） in patients with genotype B HBV were better than genotype C（22.2%,10/45 and 28.6%,4/14 respectively）.Conclusion：Genotype of HBV is related to efficacy of interferon alpha-2b.At end of treatment with interferon alpha-2b,response of patient with genotype B HBV infection is better than genotype C.