摘要
为了研究GABA与MOR在吗啡镇痛中的相互关系,用包埋前免疫组织化学方法结合包埋后胶体金电镜技术,观察了猫脊髓后角浅层内γ-氨基丁酸(GABA)能轴突终末与表达阿片μ受体神经元之间的突触联系。结果表明,后角浅层内约有三分之一的MOR阳性树突和胞体与GABA阳性终末形成突触连接,这些突触均为对称性突触。
The synaptic relationship between GABAergic axon terminals and neurons expressing μ opioid receptor(MOR)in the superficial spinal dorsal horn of the cat was examined by using pre embedding immunohistochemical method combined with post embedding immunogold technique.About one third of the cell bodies and dendrites showing MOR like immunoreactivity formed synaptic contacts with GABAergic axon terminals;all these synapses were symmetric.The present results suggest MOR positive neurons in the superficial layers of the cat spinal cord may be modulated by GABA releasing from presynaptic axon terminals.
出处
《解剖学报》
CAS
CSCD
北大核心
1998年第3期225-227,I001,共3页
Acta Anatomica Sinica
基金
国家自然科学基金
关键词
阿片Μ受体
神经元
镇痛
脊髓
猫
Γ-氨基丁酸
μ Opioid receptor
GABA
Electron microscopy
Immunohistochemistry
Spinal cord
Cat