胃肠间质瘤共识解读和个体化治疗

Interpretation of clinical practice guidelines and personalized therapy of gastrointestinal stromal tumor

胃肠间质瘤(GIST)虽不常见,但其发病机制的研究和临床治疗的成功经验可为治疗其他肿瘤以启发。对于这个较新的肿瘤概念,知识更新和规范诊疗意义重大。美国综合癌症网络(NCCN)每年至少对该病的诊疗指南更新2次。随着对该病的持续深入研究和临床诊治经验的积累,发现GIST的治疗也存在一定的个体差异。通过近年来对于瘤组织基因突变情况与靶向治疗关系的研究、微创手术治疗GIST,以及靶向治疗联合手术治疗该病的经验的积累,已初步形成一些对GIST个体化治疗的经验。

Gastrointestinal uncommon in clinical practice successful molecular targeted stromal tumor （GIST） is But it brought a renovation in therapy which inspires novel investigations in other tumor entities. As a lately recognized type of tumor, GIST is under heated researches. Clinical practice guidelines of GIST have been revised at least twice a year by National Comprehensive Cancer Network （NCCN）. More experiences and clinical data have been reported in more than a decade, and more variations in the pathogenesis and clinical outcome of the tumor have been noticed. It seems that a time calling for personalized therapy of GIST has come, based on researches of related mutation status and the efficacy of targeted therapy, the role of minimally invasive surgery in GIST and combined surgery and targeted therapy in advanced GIST.