NSE,CgA,Syn在神经内分泌肿瘤诊断中的应用

Expression of NSE, CgA and Syn in neuroendocrine tumors

目的：探讨神经内分泌肿瘤诊断中神经元特异性烯醇化酶（ＮＳＥ），嗜铬素Ａ（ＣｇＡ），突触素（Ｓｙｎ）的应用价值。方法：应用免疫组化ＬＳＡＢ法对９９例不同部位及激素活性的神经内分泌肿瘤进行ＮＳＥ，ＣｇＡ，Ｓｙｎ标记。结果：３种标记物在神经内分泌肿瘤中的阳性率分别为ＮＳＥ９４．９％，ＣｇＡ７０．７％，Ｓｙｎ７５．８％。３种标记物共同表达率为５８．６％，高于单项（１５．２％）和双项（２５．３％）标记物表达率，有９８例标本至少显示１种标记物阳性。结论：３种标记物的表达与肿瘤部位和激素活性无关。

Purpose To evaluate the expression of NSE, CgA, Syn in neuroendocrine tumors. Methods Ninty nine cases of different locational and functional tumors of the neuroendocrine system were investigated immunohistochemically with antibodies against NSE, CgA, and Syn. Results The positivity rates of NSE, CgA, Syn in neuroendocrine tumors were 949%, 707%, 758% respectively. The positivity rate of common expressions of the three markers was 586%, which was higher than the expression of single marker (152%) or two markers (253%). At least one marker was expressed in almost every tumor. Conclusion The expressions of NSE, CgA and Syn have no relationship with neuroendocrine tumors sites and hormone activitives. Combined application of three markers may raise the diagnostic rate of neuroendocrine tumors.