血管性抑郁症与非血管性抑郁症患者认知功能障碍的对比研究

Control Research on Cognitive Impairment of Vascular Depression and Non-vascular Despression

目的探讨血管性抑郁患者与非血管性抑郁患者认知功能障碍的差异。方法采用汉密尔顿抑郁量表(HAMD)和简易智能精神状态检查量表(MMSE),对36例血管性抑郁患者和32例非血管性抑郁患者的临床特征进行比较研究。结果血管性抑郁症患者的MMSE总分(χ2=20.56,24.16)及即刻记忆(χ2=2.33,2.97)、短程记忆(χ2=2.18,2.97)、计算力(χ2=3.34,4.42)、语言理解(χ2=2.55,2.99)和表达因子分(χ2=0.77,0.96)分值均显著低于非血管性抑郁症患者组,(P均<0.05)。结论血管性抑郁症具有独特的发病特征,其认知功能损害比非血管性抑郁症较严重。

Objective To investigate the differences of cognitive impairment between vascular depression and non-vascular depression.Methods The Hamilton Depression Rating Scale（HAMD）and the Mini-mental State Examination（MMSE）were used.A total of 36 cases of vascular depression patients and 32 cases of non-vascular depression in patients with clinical features of a comparative were taken into the study.Results The vascular depression group of patients with MMSE total score and immediate memory,short-term memory,calculation ability,language comprehension and expression of factor sub-scores were significantly lower than thosd of non-vascular depression group（P0.05）.Conclusion The vascular depression has a unique clinical characteristics,their cognitive impairment is more serious than non-vascular depression.