摘要
采用完全随机同期对照方法,对家兔桡骨节段性缺损动物模型,分别植入自制脱钙牙本质基质(DDM)、生物活性玻璃陶瓷(BGC)与脱钙牙本质基质复合物、脱钙骨基质(DBM)整复骨缺损,行X线观察及新骨钙磷元素动态变化的测定。结果显示:用DDM整复的骨缺损区在术后各程期的X线表现与DBM相似,第8周时新旧骨界线消失,髓腔再通;而DDM加BGC的骨整复区在第8周时虽然骨断端新旧骨的界线消失,但新骨的X线表现仍为一阻射团块;空白对照侧在术后8~12周X线表现为骨断端成锥形,断端间无骨性愈合。新骨X线能谱分析结果显示,DDM和DBM组内各程期Ca/P值有显著性差异(P<0.01);除DDM及DBM第12周时的Ca/P值外,3种材料各程期新骨Ca/P原子个数比与正常骨相比有显著性差异(P<0.
A model of segmental bone defect in radius of rabbit was employed, and DDM,DBM and DDM+BGC were implanted in the left and right defect regions of 48 New Zealand rabbits respectively.The samples were sacrificed in 1,2,3,4,8,12 weeks after operation,then X ray examination and electromicroscopic Ca/P atom amount ratio measurement were performed.The results showed that DDM group and DBM group presented a completely medullary reconstruction while DDM+BGC group did not demonstrate reconstruction of medullary cavity 8 weeks postoperatively. The three kinds of materials showed the good reconstruction capacities of bone defect,and Ca/P analysis was also in cooperation with the X ray observations.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1998年第3期267-269,I011,共3页
West China Journal of Stomatology
关键词
牙本质
骨生成
骨形成蛋白
钙磷
骨缺损
dentin osteogenesis\ \ bone morphogenetic protein\ \ X-ray examination\ \ Ca\ \ P