血管内皮生长因子在儿童肾母细胞瘤中表达的Meta分析

Meta-analysis of expression and significance of vascular endothelial growth factor in Wilms tumor in children

目的探讨血管内皮生长因子（VEGF）在儿童肾母细胞瘤中的表达及其意义。方法检索中国学术期刊网全文数据库、万方及维普数据库，收集国内1994—2009年公开发表的关于VEGF在儿童肾母细胞瘤中的表达及意义的独立病例对照研究资料，并对文献进行异质性检验，以OR值为效应指标，应用Mem分析软件RevMan4．2．2对各研究原始数据进行统计学处理，计算合并OR值及95％CI。结果最终进入系统评价的文献共有3篇病例对照研究，其中儿童肾母细胞瘤98例（病例组），对照组48例。病例组中VEGF阳性表达数为56例，对照组为7例，合并OR值为6．66，95％CI为2．71—16．40，P〈0．01。VEGF表达与临床分期之间存在明显相关性（P〈0．01），而与组织类型（P〉0．05）、肿瘤转移（P=0．05）无明显相关性。结论VEGF的表达可能在儿童肾母细胞瘤的发生、发展中起重要作用，对临床医师判断病情与治疗可起到一定的指导作用。

Objective To explore the expression and significance of vascular endothelial growth factor （VEGF） in Wilms tumor. Methods Documents published in Wilms tumor from 1994 to 2009 were retrieved through CNKI, Wanfang databases and VIP on case-control studies associated with VEGF and Wilms tumor. Taking into account the possible heterogeneity of the studies, a statistical test for heterogeneity was performed. The odds ratio and 95%CI were used to evaluate the risks of the expression of VEGF in Wilms tumor. The Meta-analysis was applied with RevMan 4.2.2 software. Results Three of the case-control studies were selected for this Meta-analysis, including 98 Wilms tumor cases （case group） and 48 control （control group）. The expression of VEGF was 56 in case group and 7 in control group. The pooled odds ratio was 6.66, and the 95%CI was 2.71-16.40（P 〈 0.01 ）. The expression of VEGF was related to clinical staging （P 〈 0.01 ）, but was not related to tissue type （P 〉 0.05 ） and tumor metastasis （P = 0.05 ）. Conclusion VEGF may play an important role in the pathway of Wilms tumor progression and metastasis of Wilms tumor, and it is feasible for early diagnosis, treatment and precaution.