纤维瘤病的临床病理和免疫组化分析

A clinicopathological and immunohistochemical study of fibromatosis

目的：探讨纤维瘤病的组织发生和临床病理特征。方法：对１６例手术切除的纤维瘤病标本进行了光镜观察和免疫组织化学ＬＳＡＢ法染色。结果：腹壁及腹壁外的纤维瘤病表达ＡＳＭＡ和Ｓ－１００蛋白，Ｓ－１００蛋白阳性细胞呈散在分布，复发的２例ＰＣＮＡ呈弱阳性。肿瘤的主要成分为肌纤维母细胞，并可以见到Ｓ－１００阳性表达。

Purpose To investigate the histogenesis and clinicopathological characteristics of fibromatosis. Methods Sixteen cases of fibromatosis were studied by light microscope and immunohistochemical (LSAB method). Results The extraabdominal and abdominal fibromatosis showed alpha smooth muscle actin or S 100 expression, neurilemmal cell in tumor tissues was scattered distribution, two cases of recurrence was weak for PCNA,the tumor was major composed of myofibroblast. It was found that the fibromatosis was differentiating into neurilemmal cell and synovium fissure. Conclusion The fibromatosis is originated from the primitive nucommited mesenchyme.