慢性乙型肝炎肝内血管病变组织学随访观察

Follow up studies on pathological changes of intrahepaticvessels in chronic hepatitis B

目的：观察慢性乙型肝炎（乙肝）肝内血管病变在病理发生和发展中的作用。方法：用ＨＥ、组织化学、免疫组织化学及光镜技术，对１０４例乙肝患者首、末２次肝活检标本进行观察。结果：肝内血管病变有血管炎症、破坏、阻塞、增生及肝窦毛细血管化表现，是乙肝的一大组织病理学特征，与其肝实质变性、坏死、肝纤维化、肝硬变及预后密切相关。结论：肝内血管病变在乙肝的病理发生和发展中可能有重要作用。故在治疗中及时有效地改善其肝脏血供障碍，是亟待研究解决的课题。

Objective:To study the effect of vascular damages on pathogenesis of chronic hepatitis B.Methods:Pathological examinations were made in 104 cases of chronic hepatitis B,with 2 biopsies(an initial,a final) taken from each patient.Results:Inflammatory damage,proliferation and obstruction in intrahepatic vessels and capillarization in the sinusoid were the histopathological features of hepatitis B,which were closely related to liver parenchyma degeneration and necrosis,fibrosis,cirrhosis also the prognosis of the disease.Conclusions:Damage in blood supply is the main cause of the pathological changes in liver of chronic hepatitis B,it should be corrected in treatment.