结肠癌中Survivin的表达及临床意义

Study on Surviving Protein Expression in Colorectal Carcinoma

目的:应用免疫组化技术研究并探讨生存互(survivin)在结肠癌组织中的表达及其意义。方法:采用免疫组化技术检测10例结肠正常粘膜组织与30例结肠癌组织标本中survivin的表达。结果:正常结肠粘膜组织中survivin呈阴性表达,结肠癌中survivin的阳性表达率为53.3%(16/30)。Survivin蛋白在正常结肠粘膜组织、结肠癌组中的表达水平有显著差异(P<0.05),在结肠癌中的表达与结肠癌的侵袭深度、Dukes分明、淋巴结转移有关(P<0.05),而与患者年龄、性别、组织学分裂、分化程度无明显相关性(P>0.05)。结论:Survivin表达可能对结肠癌的早期诊断和判断结肠癌的恶性生物学行为有一定价值。

Objective：To study the expression and significance of surviving protein in colorectal carcinoma.Methods：The expression of surviving protein in 10 cases of the normal mucosa and in 30 cases of colorectal carcinoma was detected by immunohistochemistry SP.Results：The positive expression rate or surviving protein was 0 in normal mucosa and 53.3%（16/30） n colorectal carcinoma.There was an obvious difference between normal and cancer tissue.Conclusion：The result revealed that Survivin may play an important role in the early stage of colorectal cancer.Survivin many be a marker of early diagnosis and the new gene therapy target of colorectal cancer.