氟比洛芬酯的药理作用和临床应用进展

Pharmacologic action and clinical application progress of flurbiprofen axetU

氟比洛芬酯注射液是一种新型的非甾体类抗炎镇痛药，由脂微球和其所包裹的氟比洛芬酯组成，进入血液后被血中的酯酶迅速水解成活性的氟比洛芬，其镇痛机制主要是通过抑制前列腺素合成来达到镇痛目的。脂微球对其所包裹的药物具有靶向性，控制包裹药物的释放，易于跨越细胞膜从而促进药物吸收，进一步缩短起效时间。氟比洛芬酯注射液已用于围术期镇痛、癌痛治疗等。本文综述其药理作用和临床应用进展。

The fluorine is profuse the ester inoculation fluid compared to the Luo river is one kind of new non--steroid body class anti--SARS analgesic, and its wraps the fluorine by the fat microballoons to be profuse the ester compared to the Luo river to be composed, after entering the blood, by blood＇s in esterase rapid hydrolisis survive fluorine compared to the Luo river fragrance, its analgesia mechanism is mainly through suppresses the prostaglandin synthesis to serve the analgesia purpose. The fat microballoons to the medicine which its wraps have the target tropism, the control wrap the medicine the release, easy to surmount the cell mem- brane, thus the promotion medicine absorption, further reduces the effect time. The fluorine is profuse the ester inoculation fluid compared to the Luo river to use in encircling the technique time analgesia, the cancer pain treatment and so on. This article sum- marizes its pharmacological action and the clinical practice progress.