HBeAg阴性与HBeAg阳性乙肝肝硬化患者临床相关因素对比分析

Comparison of Clinical Related Factors between Cases with HBeAg-negative and HBeAg-positive Liver Cirrhosis

目的探讨HBeAg阴性与HBeAg阳性肝炎肝硬化的临床相关因素异同。方法对424例乙肝肝硬化中HBeAg阴性与HBeAg阳性肝炎肝硬化患者HBV-DNA水平、并发症和Child-pugh分级资料进行回顾性分析。结果424例乙肝肝硬化中HBeAg阴性患者252例,占59.43%;HBeAg阳性患者172例,占40.57%;HBeAg阴性组年龄明显高于HBeAg阳性组(P<0.05);HBeAg阴性组HBV-DNA水平低于HBeAg阳性组(P<0.05);HBeAg阴性组原发性肝癌发生率高于HBeAg阳性组(P<0.05);两组间性别、各并发症发生率和Child-pugh分级水平、差异无统计学意义(P>0.05)。结论乙肝肝硬化中HBeAg阴性患者年龄较大、HBV-DNA水平较低、原发性肝癌发生率较高;HBeAg阴性组和阳性组在其它并发症发生率和病情轻重方面未见区别。

Objective To investigate and compare the clinical characteristics of HBeAg-negative and HBeAg-positive liver cirrhosis.Methods A total of 424 hospitalized cases with HBeAg-negative and HBeAg-positive liver cirrhosis were analyzed retrospectively.The factors included age,gender,constitutes of liver cirrhosis,HBVDNA level,complications and Child-pugh graduation.Results HBeAg-negative liver cirrhosis patients group totally 252 cases,215 male and 37 female,the gender ratio was roughly 5.81：1.HBeAg-positive chronic liver Diseases patients group totally 172 cases,149 male and 23 female,the gender ratio was roughly 6.48∶1.The serum HBVDNA levels in HBeAg-negative patients group was lower than that in HBeAg-positive patients group（P0.01）.No significant difference was found in upper gastrointestinal hemorrhage,hepatic encephalopathy,infection of abdominal cavity,electrolyte disturbances and hepatorenal syndrome between two groups（P0.05）.Conclusion HBeAgnegative patients had older age and lower HBV DNA level than HBeAg-positive patients had.