平阳霉素微小剂量与常规剂量治疗婴幼儿口腔颌面部血管瘤的临床观察

Effect of Microdose Pingyangmycin and Routine Dose Pingyangmycin on Hemangioma in Oral and Maxillofacial Regions of Infants

目的比较微小剂量平阳霉素（PYM）和常规剂量平阳霉素瘤内注射治疗婴幼儿口腔颌面部血管瘤的疗效。方法收集两组婴幼儿血管瘤患者,一组52例采用微小剂量PYM（浓度为0.2mg.mL-1）瘤内注射治疗,另一组45例采用常规剂量PYM（浓度为1mg.mL-1）瘤内注射治疗,两组均间隔2周或更长时间（视肿胀消退程度）重复注射,2~10次治疗结束。结果3、6、9个月随访观察,两组间的疗效差异无统计学意义（Z=-1.293,P=0.196）。两组的不良反应差别也无统计学意义。结论微小剂量PYM治疗婴幼儿口腔颌面部软组织血管瘤能获得常规剂量的临床疗效,值得临床推广使用。

Objective To evaluate the effect intralesional injection of microdose pingyangmycin and routine dose pingyangmycin on hemangioma in the oral and maxillofacial region of infants.Methods 52 infant patients with hemangioma in oral and maxillofacial regions were injected the microdose Pinyangmycin into the lesions or in the vicinity of the hemangioma.45 infant patients with hemangioma in oral and maxillofacial regions were injected the routine dose Pinyangmycin into the lesions or in the vicinity of the hemangioma.The injection would be repeated every 2 weeks or more in two groups when necessary,and this process could be repeated 2 to 10 times.Results The effect of these two groups showed no significant difference.Conclusion The microdose pingyangmycin in treatment of hemangioma in the oral and maxillofacial region of infants was a safe,simple and effective therapv to manage venous malformation in the oral and maxillofacial regions.