质子泵抑制剂对钙调激素及尿钙水平的影响

Influence of proton pump inhibitors on levels of urinary calcium and calcium regulating hormones

目的探讨短期使用质子泵抑制剂是否导致尿钙水平的下降及钙调激素的变化问题。方法随机筛选97例住院患者,各观察对象因病情需要每日使用治疗剂量的质子泵抑制剂,疗程3个月。各病例于治疗前后分别检查血清总钙、24h尿钙、甲状旁腺素、降钙素、骨钙素。结果质子泵抑制剂治疗3个月后各观察对象血钙水平、甲状旁腺素、降钙素、骨钙素无显著变化,24h尿钙水平下降,与治疗前比较差异有统计学意义(P<0.01)。结论短期使用质子泵不会影响血钙及钙调激素水平,但会导致尿钙水平下降,有可能与质子泵抑制剂(PPI)抑制钙吸收有关。

Objective To investigate the effects of proton pump inhibitors （PPI） on levels of calcium regulating hormones and urinary calcium. Methods Ninety-seven patients received PPI therapy for three months were recruited in this study. Blood levels of PTH,BPG,CT,serum tolal calcium and 24 hours urine calcium were measured before and after treatment. Results There were no significant changes in level of PTH, BPG, CT and serum tolal calcium after therapy. The level of 24 hours urine calcium decreased after therapy compared with that before treatment. Conclusion Short-term therapy with PPI can lead to the decrease of level of 24 hours urine calcium. The reason could be related to the inhibitory effect of PPI on calcium absorption.