药物性肝损害41例临床分析

Clinical analysis on 41 case of drug induced liver injury

目的分析药物性肝损害(DILI)的病因及临床特点,提高对药物性肝损害的认识。方法对本院41例药物性肝损害患者的临床资料进行回顾性分析,根据服药时间及服用药物种类、临床表现、肝损害的分型进行综合评价,总结药物性肝损害的临床特点。结果引起肝损害的药物前3名依次为:中草药及中成药14例(32.6%),抗生素10例(23.3%),降压药5例(11.6%)。临床分型:肝细胞损伤型13例,占31.7%;胆汁淤积型15例,占36.6%;混合型12例,占39.3%。结论临床上多种药物可导致肝损害,因此在使用有肝损害副作用药物时,应及时检测肝功能,以求早发现、早治疗。

Objective To analyze the etiology and clinical feature of drug induced liver injury （DILI）, and increase the recognition of DILL Methods The retrospective study on the clinical data of 41 cases of DILI in our hospital from 2006 to 2009 was performed, based on the history of taking medicine, clinical situation,type of DILI, the general evaluation was performed and the clinical feature of DILI was summarized. Results In these patients, the first three drugs injuring liver were in order ：Chinese traditional medicine （14 cases ,32. 6% ）, antibiotics（ 10 cases, 23.3% ） ,hypotensivc drug （5 cases, 11.6% ）. The clinical types included hepatocellular injury type （ 13 cases, 31. 7% ）, cholestatic injury type （15 cases ,36. 6% ）,mixed type （12 cases,39. 3% ）. Conclusion DILl could be induced by lots of medicines, the hepatic function should be examined in time when take those medicines in order to find and treat the patients early.