胃肠道间质瘤的分子学认识进展

The molecular recognition of gastrointestinal stromal tumors

胃肠道间质瘤作为消化道常见的间叶源性肿瘤目前已在基础及临床工作上开展多年的研究,对于其认识,经过了从组织来源的最终认识到目前在基因层面的深层了解以及由此引发的在临床工作当中对胃肠道间质瘤药物治疗的敏感性较强的伊马替尼的发现,胃肠道间质瘤的研究一直在人们的关注下取得了骄人的进展,该文在前人已有研究的基础上从分子水平阐释胃肠道间质瘤发病的可能内在机理。

Gastrointestinal stromal tumors （GIST） as a kind of frequent enteron tumor which originate from lobus intermedius tissue have been taken into basic and clinical research for many years. With the continuous research people make a gradual realization of GIST primordially from tissue origin to nowadays gene level on basis of which Imatinib has been manufactured in the process of clinic work to cure GIST more sensitively than other chemotherapeutics. In such conditions the research concerning GIST has been made a excellent progression under the care of scientists. In this paper a summary of previous study of predecessor would be made to explain the molecule generating mechanism of GIST.