利用改变装填量对循环系统药物释放进行控制

Control for Drug Release of Circulating System by Parameter of Drug Installation Capacity

本文将化学工程学原理应用于药物控制释放这一交叉学科，针对膜相控制释放进行了动力学研究．建立、推导了“准稳态、环境浓度不断提高的释放动力学模型”，解决了现有模型“环境介质为无限渗阱”假设产生的偏差，使模型更接近于实际释放过程．利用药物装填量这一容易调节的参数对循环系统药物释放进行控制．设计了聚乙烯醇／维生素B2混合药膜的圆筒壁循环释放体系．利用该体系验证了本文所建立的模型．

The principle of chemical engineering was applied to drug delivery. An pseudo state delivery kinetics model with environment density increase was established to replace the 'Environment Medium Seeped Trap Assumption' which deviates from the real delivery process. Drug release of circulating system was controlled by the parameter of drug install capacity. A new poly(ethylene-vinyl alcohol)/vitamin B_2 cylinder delivery system was designed and used to verify the model. The results showed that the model was effective in describing and predicting the delivery livery behaviors for a diffusion-controlled polymer/drug release system.