离子液体中酮肟O-烷基化反应的研究

O-Alkylation of Ketone Oxime in Ionic Liquids

以[Bmim]PF6,[Bmim]BF4,[Bmim]OH为介质,以NaOH为缚酸剂,由酮肟与卤烷、硫酸酯等烷基化剂在20～40℃反应1～2h,以52%～94%的收率制备了酮肟醚衍生物,产物结构经1HNMR,GC-MS表征.结果表明,该方法简便易操作,所用离子液体对环境友好,并可循环使用.

A series of ketone oxime ethers were synthesized by O-alkylation of ketone oxime with several alkylating agents such as alkyl halides and alkyl sulfates in ionic liquids. The O-alkylation reactions were conducted in 20-40 ℃ for 1 --2 h, using ionic liquids [Bmim]PF6, [Bmim]BF4 and [Bmim]OH as medium and NaOH as acid binding agent. The yields of 52%-94% were obtained and the products were identified by 1H NMR and GC-MS techniques. The study shows that the operation conditions are mild, the process is simple and green to environment, and the ionic liquids could be reused while maintaining good performance.