埃索美啦唑与法莫替丁联合治疗非糜烂性胃食管反流病

Efficacy of treating esoprazol combined with famotiding treating non-erosive reflux disease

目的观察埃索美啦唑与法莫替丁联合治疗非糜烂性胃食管反流病(NERD)的疗效。方法86例NERD患者根据24h动态pH监测分为:阳性组及阴性组,各随机分为治疗组和对照组,治疗组清晨顿服埃索美啦唑40mg,夜间睡前服法莫替丁40mg,对照组仅清晨顿服埃索美啦唑40mg,两者均予西沙比利5mg,1日3次,疗程8周。治疗前及疗程结束后行胃镜检查,24h动态pH监测,观察其胃镜表现及反流症状的改善程度。结果阳性治疗组23例中治愈17例,有效5例,无效1例,总有效率95.7%,对照组23例中治愈10例,有效6例,无效7例,总有效率69.6%。阴性治疗组20例治愈8例,有效7例,无效5例,总有效率为75%,对照组20例治愈7例,有效5例,无效8例,总有效率为60%。结论埃索美啦唑与法莫替丁联合治疗NERDPH监测阳性的患者的疗效明显优于单用埃索美啦唑者(P<0.05),而对于PH阴性的患者无明显差异。

OBJECTIVE To study the efficience of esoprazol combined with famotiding treating Non-Erosive Reflux Disease;METHODS 86 cases with NERD were randomLy divided into two groups by 24 hour pH monitoring：the masculine group and negative group,each group was randomLy divided into control group and theraphy group.The both masculine group were given esoprazol 40mg in the morning and famotiding 40mg nightly.The both negative group were given esoprazol 40mg in the morning.All cases were treated with cisapride 5mg Tid.The course of treatment was 8 weeks.Endoscope examination was perfomed before treatment and after the course of treatment,and then theendoscopic apperence and reflux symptons were observed.RESULTS In the masculine theraphy group 17 cases were cured,5 cases were partly effective,and 1cases were ineffective,with the total efficiency was 95.7%,In the masculine control group 10 cases were cured,6 cases were partly effective,and 7cases were ineffective,with the total efficiency was 69.6%,In the negative theraphy group 8 cases were cured,7 cases were partly effective,and 75cases were ineffective,with the total efficiency was 75.0%,In the negative control group 7 cases were cured,5 cases were partly effective,and 8cases were ineffective,with the total efficiency was 60%.CONCLUSION The efficacy of esoprazol combined with famotiding is obviously superior to the solo theraphy of esoprazol in positive group of 24 hour pH monitoring,but not obviously superior in negative group of 24 hour pH monitoring.