^(14)C-尿素呼吸试验在幽门螺杆菌根除治疗前后的检测价值

The Value of ^(14)C - Urea Breath Test before and at 1 and 3 Months after Eradication of H. Pylori in Patients with Duodenal Ulcer

观察短程新三联抗菌药物在十二指肠溃疡患者中的根除效果及14C-尿素呼吸试验（14C－UBT）在治疗前后的检测价值。方法：56例十二指肠溃疡患者，经内镜活检组织快速尿素酶试验，Warthin－Starry染色及14C－UBT检查，二项阳性者诊断为HP感染。阳性患者给予奥美拉唑（Losec20mgBid）、克拉霉素（Qacid0．5Bid）及替哨唑（Tinidazole0．5Bid）治疗1周，疗程结束后1月及3月分别进行14C-UBT检测HP。结果：十二指肠溃疡患者HP感染率为94．7％。54例阳性患者抗HP治疗1月及3月后HP的根除率分别为87％和81．4％，3例（5．5％）HP阴性患者3月后转为阳性。新三联1周疗法药物副反应发生率为9％．不影响治疗进程。结论：以PPI为基础的新三联短程抗菌治疗是一较好根除HP，的方案，病人依从性好。14C－UBT作为HP根除1月后的复查，应持谨慎态度。通过随防或结合内镜检查可更准确判断HP的根除率。

Objeetive Aims This study was to investigate the effect of a short - term, triple therapyfor eradication of H. Pylon and to determine the value of 14C - urea breath test (14C - UBT) in detectionof H,Pylori. methods 56 Patients with duodenal ulcer were diagnosed by endoscopy and H. Pylon statuswas determined by rapid urease, Warthin - Starry stein and 14C - BUT.The H. pylon positive patientswere treated with Omeprazole (Losec 20mg Bid), Claramycin (Clacid 0.5 Bid) and Tinidazole (0.5Bid) for one week. H. Pylon was re - detected by 14C - UBT on each Patient at 1 and 3 monthe after thetermination of treatment. Results The H. Pylori infection rate in Patients with duodenal ulcer disease was96.4% .The eradication rates of H.pylori al 1 and 3 months were 87% and 81 .4%, respectively.3H. Pylori- negative Patients at 1 month turned out positive at 3 months after therapy. No serious side effects were observed. Conclusion H. Pylori eradication by one - week's treatment with a combination ofPPI and claramycin plus tinidazole is optical. 14C - UBT is a good mothod to detect H. Pylon infection before treatment. However, its value should be carefully evaluated after H. Pylon eradication.