摘要
观察短程新三联抗菌药物在十二指肠溃疡患者中的根除效果及14C-尿素呼吸试验(14C-UBT)在治疗前后的检测价值。方法:56例十二指肠溃疡患者,经内镜活检组织快速尿素酶试验,Warthin-Starry染色及14C-UBT检查,二项阳性者诊断为HP感染。阳性患者给予奥美拉唑(Losec20mgBid)、克拉霉素(Qacid0.5Bid)及替哨唑(Tinidazole0.5Bid)治疗1周,疗程结束后1月及3月分别进行14C-UBT检测HP。结果:十二指肠溃疡患者HP感染率为94.7%。54例阳性患者抗HP治疗1月及3月后HP的根除率分别为87%和81.4%,3例(5.5%)HP阴性患者3月后转为阳性。新三联1周疗法药物副反应发生率为9%.不影响治疗进程。结论:以PPI为基础的新三联短程抗菌治疗是一较好根除HP,的方案,病人依从性好。14C-UBT作为HP根除1月后的复查,应持谨慎态度。通过随防或结合内镜检查可更准确判断HP的根除率。
Objeetive Aims This study was to investigate the effect of a short - term, triple therapyfor eradication of H. Pylon and to determine the value of 14C - urea breath test (14C - UBT) in detectionof H,Pylori. methods 56 Patients with duodenal ulcer were diagnosed by endoscopy and H. Pylon statuswas determined by rapid urease, Warthin - Starry stein and 14C - BUT.The H. pylon positive patientswere treated with Omeprazole (Losec 20mg Bid), Claramycin (Clacid 0.5 Bid) and Tinidazole (0.5Bid) for one week. H. Pylon was re - detected by 14C - UBT on each Patient at 1 and 3 monthe after thetermination of treatment. Results The H. Pylori infection rate in Patients with duodenal ulcer disease was96.4% .The eradication rates of H.pylori al 1 and 3 months were 87% and 81 .4%, respectively.3H. Pylori- negative Patients at 1 month turned out positive at 3 months after therapy. No serious side effects were observed. Conclusion H. Pylori eradication by one - week's treatment with a combination ofPPI and claramycin plus tinidazole is optical. 14C - UBT is a good mothod to detect H. Pylon infection before treatment. However, its value should be carefully evaluated after H. Pylon eradication.
出处
《汕头大学医学院学报》
1998年第A12期1-1,共1页
Journal of Shantou University Medical College
关键词
尿素呼吸试验
幽门螺杆菌
十二指肠溃疡
治疗
^(14)C - Urea Breath Test
Helicobacter Pylori
Duodenal Ulcer
Drug Therapy