增健口服液配伍营养适粉、维康素片对T细胞免疫的增强作用

Immune-enhancement Effects of Zengjian Oral Liquid Mixed with Yingyangshi Powder and Weikangsu Tablets

本文研究增健口服液配伍营养适粉、维康素片对T细胞免疫的增强作用。以环磷酰胺造成小鼠免疫功能低下模型,观察增健口服液与营养适粉、维康素片等合用对小鼠迟发型超敏反应、胸腺及脾脏指数、外周血淋巴细胞总数和T淋巴细胞亚群的影响。结果表明:与模型对照组比较,增健+营养适组、增健+维康素组和增健+营养适+维康素组耳肿胀度、淋巴细胞总数,增健+营养适组脾脏指数均显著升高(P<0.05);与增健组比较,增健+维康素组耳肿胀度显著升高(P<0.05)。与增健组、增健+营养适组和增健+维康素组比较,增健+营养适+维康素组CD4+T细胞百分比例和CD4+/CD8+比值显著提高,CD8+T细胞百分比例显著降低(P<0.05)。结果提示增健口服液配伍营养适粉、维康素片对T细胞免疫具有增强作用。

The enhancement effects of the mixture of Zengjian oral liquid （ZJ ）, Yingyangshi powder （YYS） and Weikangsu tablets （WKS） on T cell immune of mice were studied in this paper. The effects of the mixture of ZJ, YYS and WKS on the delayed-type hypersensitivity, thymus gland and spleen index, the total number of peripheral blood lymphocytes and T lymphocyte subsets were studied in immunosuppressive mice model by cyclophosphamide. The result showed that the ear swelling and the total number of lymphocytes of the group fed with ZJ-YYS-ZJ mixture （ZJ-YYS-ZJ group）, the group fed with WKS and ZJ （WKS–ZJ group） and the group fed with YYS and ZJ （YYS-ZJ group） were obviously improved and the spleen index of the mice feed with ZJ and YYS （ZJ-YYS group） were also significantly increased （P0.05）.Compared with the ZJ group, the ear swelling of the ZJ-WKS group was significantly higher （P0.05）. Besides, the percentage of cases of CD4＋T cells and the ratio of CD4＋/CD8＋ of the ZJ-YYS-ZJ group were significantly higher （P0.05） than those of ZJ group, WKS–ZJ group and YYS-ZJ group, while the percentage of cases of CD 8＋ T cells of ZJ-YYS-ZJ group were significantly decreased （P0.05）. It was concluded that the mixture of ZJ, YYS and WKS could improve the T-cell immune.