摘要
目的探讨戊型肝炎患者外周血T淋巴细胞亚群的变化及其免疫学意义。方法应用流式细胞仪检测136例急性戊型肝炎患者及13例正常人群的外周血T细胞亚群。结果戊型肝炎患者与正常人比较,T淋巴细胞亚群变化无统计学差异(P>0.05)。单纯戊型肝炎病毒感染组的CD3+细胞总数、CD4+和CD8+细胞绝对数均高于重叠乙型肝炎病毒感染组(P均<0.05)。结论戊型肝炎病毒感染患者存在宿主细胞免疫功能的改变,这可能与急性戊型肝炎肝细胞损伤和清除病毒有关。
Objective To measure the change of T lymphocyte subsets in patients with acute hepatitis E（HE） and evaluate its immunological significance.Methods The levels of T lymphocyte subsets in 136 patients with acute HE and 13 normal controls were measured by using flow cytometry.Results None of the T lymphocyte subsets showed significant difference between the patients with HE and the normal group.The absolute number of CD＋3,CD＋8 and CD＋4 T lymphocyte were significantly increased in patients with solo hepatitis E virus（HEV） infection than those of superinfected with HBV（P0.05）.Conclusion HEV infection may lead to the change of T lymphocyte immune function,which may contribute to the hepatocyte impairment and the clearance of the virus in HEV patients.
出处
《山东医药》
CAS
北大核心
2010年第16期2-4,共3页
Shandong Medical Journal
基金
国家863课题基金资助项目(2006AA02Z453)
