儿童哮喘发作期血浆脂联素和抵抗素水平变化及意义

The Change of Plasma Adiponectin and Resistin Levels and Its Significance in Children with Asthma Attack

目的：通过观察两组儿童血浆中脂联素（adiponectin,ADP）和抵抗素（resistin,ADSF）水平的变化,初步探讨ADP与ADSF在哮喘发病中的作用及其两者的相关性。方法：采用酶联免疫吸附实验（ElISA）测定40例4-14岁支气管哮喘患儿发作期血浆中ADP和ADSF水平,与40例同年龄段健康小儿血浆水平做统计分析。结果：ADP在实验组与对照组之间无统计学意义（P〉0.05）;实验组ADSF明显高于对照组,有统计学意义（P〈0.05）;ADP与ADSF水平变化两组均无相关性（r值分别为-0.127、-0.227,P值均大于0.05）。结论：ADSF可能参与哮喘发病,其水平增高提示哮喘存在,ADP与儿童哮喘发生无直接关系。

Objective：Through observation of plasma adiponectin（ADP） and resistin（ADSF） levels of two groups of children,toanalyze the rose of ADP and ADSF in asthma attack and the correlation between ADP and ADSF.Methods： Determing the plasma levels of ADP and ADSF by enzyme-linked immunosorbent assay（ElISA）,children with asthma attack and the normal respective 40 case,analyze the two groups of date.Results：ADSF of experimental group was significantly higher than the normal（P〈0.05）;threr are no significance difference between the two groups ADP levels.（P〉0.05）;ADP and ADSF levels in both groups were not correlated（rvalues-0.127,-0.227 respectivly,P〉0.05）.Conclusion： ADSF may be involved in pathogenesis of asthma,which maybe suggests exist asthma,ADP has not directly relationship with asthma tact.