布地奈德混悬液足量雾化吸入治疗老年慢性阻塞性肺疾病急性加重期的临床观察与分析

Observation and analyse of inhaling Suffcient Budesonide in Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Old people

目的:观察足量雾化吸入布地奈德混悬液治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:将60例AECOPD患者随机分为治疗组和对照组,分别为30例。治疗组使用布地奈德混悬液2mg,每隔8 h雾化1次,对照组使用甲泼尼龙片32 mg 1次/d口服,记录两组患者用药7 d前后PaO2,PaCO2FEV1变化,同时观察不良反应及疗效。结果:治疗组总有效率86.67%,对照组总有效率89.29%,两组疗效相比无统计学意义(P>0.05),两组患者治疗前后PaO2,PaCO2,FEV1均有改善。治疗前后相比差异有统计学意义(P<0.05),且治疗组副作用明显少于对照组。结论:足量雾化吸入布地奈德混悬液能改善AE-COPD患者的肺功能及临床症状与全身使用糖皮质激素疗效相近,但副作用明显较后者减少。

Objective：To observe the clinical effect of nebulized budesonide on acute exacerbated of chronic obstructive pulmonary disease.Methods： 60 patients with AECOPD were randomly divided into two groups：The observed group of 30 patients were given the budesonide suspension 2 mg q8 h nebulized inhalation,the control group of 30 patients were given 32 mg oral methylprednisolone per day.Recorded the changes of PaO2,PaCO2,FEV1 on 1st day and the 7th day,then analysis both effect and side effect.Results： The rate of observed group was 86.67% while the rate of control group was 89.29%,but there was no significance between the two groups（P〉0.05）;PaO2,PaCO2,FEV1 of the patients of two groups both improved,there was statistical significance between the treatment group and control group（P〈0.05）.The side effect of the observed group was obviously less than that of the control group.Conclusion： The treatment of budesonide suspension can improve the lung faction and the clinical symptom of patients with AECOPD,with less side effect,compareed with systemic administration corticosteroid hormones.