摘要
发展了一种适用范围广、高效且高选择性的官能化二硫缩烯酮的α-溴代反应.在少量水存在下,在四氢呋喃溶液中,以溴化铜为溴代试剂,经由官能化二硫缩烯酮(1)的α-溴代反应制备了结构多样的α-溴代二硫缩烯酮(2).
Functionalized ketene dithioacetals are important intermediates in organic synthesis.α-Functionalization reactions based on them provide potential precursors for the construction of usefully carbo-and heterocyclic compounds.In this paper,a versatileα-bromination of functionalized ketene dithioacetals was developed.In the presence of H2 O,the reactions of functionalized ketene dithioacetals(1) with CuBr 2 in THF at room temperature gave variousα-bromo ketene dithioacetals(2) in excellent yields with high regioselectivities.The mechanism of thisα-bromination is proposed to undergo an addition of bromine formed in situ to compound 1 and sequontial elimination of theα-proton.The simplicity of execution,mild conditions,inexpensive,easily usable brominating agent and high yields,make this synthetic method attractive for practical applications.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第4期727-730,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20872015)
东北师范大学分析测试基金(2009)资助
关键词
官能化二硫缩烯酮
溴化铜
α-溴代反应
Functionalized ketene dithioacetal
Cupric bromide
α-Bromination