双花华蟹甲草化学成分的研究

Chemical constituents from Sinacalia davidii

目的:研究我国特有植物双花华蟹甲草Sinacalia davidii化学成分。方法:利用硅胶色谱和Sephadex LH-20色谱手段进行分离纯化,应用NMR等方法鉴定结构。结果:从双花华蟹甲草中分离得到6个化合物,分别鉴定为β-谷甾醇(1),3-氧-2,α23-二羟基-齐敦果-12-烯-28-酸(2),28-羟基-齐敦果-12-烯-3,11-二酮(3),3α-甲氧基-齐敦果-11-酮-18-烯(4),木犀草素(5)和2α-羟基乌索酸(6)。结论:以上6个化合物均为首次从双花华蟹甲草中分离得到。

Sinacalia davidii（Franch） Koyama.grows only in China,its chemical constituents have never been studied before.The compounds were isolated by column chromatography on silica gel and Sephadex LH-20,and the structures were identified on spectroscopic data（MS,1H-NMR,13C-NMR）.Six compounds were isolated from S.davidii,and were characterized as β-sitosterol（1）,3-oxo-2α,23-dihydroxy-olean-12-en-28-oic acid（2）,28-hydroxy-olean-12-en-3,11-dione（3）,3β-methoxy-olean-11-oxo-18-ene（4）,luteolin（5） and 2α-hydroxy-ursolic acid（6）.All the six compounds above were isolated from S.davidii for the first time.