海绵Spongia sp.的化学成分研究

Chemical constituents of a new species of Spongia sponge

目的:研究海绵Spongia sp.的化学成分。方法:对海绵Spongia sp.乙醇提取物进行柱色谱分离,根据各种谱学技术和理化性质研究及GC-MS联机检索确定化合物的结构。结果:从海绵Spongia sp.中分离得到9个化合物,分别为十六碳酰基-1,3,5-三羟基-2-氨基-二十七烷(1),豆甾-4-烯-3β,6β-二醇(2),甘油酯(3),谷甾醇(4),胸腺嘧啶(5),柳珊瑚甾醇(6),鲨肝醇(7),尿嘧啶(8)和胸腺嘧啶脱氧核糖苷(9);对其中的甾醇类化合物,经GC-MS联机检索,鉴定了21个甾醇化合物。结论:十六碳酰基-1,3,5-三羟基-2-氨基-二十七烷(1)是1个新的神经酰胺。

Chemical constituents of a new species of Spongia sponge collected from Sanya bay in Hainan province,were analyzed.Nine secondary metabolites 1～9 were isolated.On the basis of their spectroscopic data and chemical degradation,their chemical structures were determined as palmitoyl-heptacosane-1,3,5-triol（1）,stigmast-4-en-3β,6β-diol（2）,2,3-dihydroxypropanyl hentetracosanate（3）,sitosterol（4）,thymine（5）,gorgosterol（6）,batyl alcohol（7）,uracil（8） and thymidine（9）.Palmitoyl-heptacosane-1,3,5-triol（1） is a new compound.