京尼平苷对慢性前列腺炎大鼠的治疗作用

Effects of geniposide on treating experimental chronic prostatitis rats

目的:探讨京尼平苷对慢性前列腺炎(chron ic prostatitis,CP)模型大鼠的作用。方法:采用前列腺内注射消痔灵方法复制慢性前列腺炎模型,随机分为模型组、阳性药组(前列康片组,2 g.kg-1)及京尼平苷高、中、低剂量组(20,10,5 mg.kg-1)。观察给药后各组大鼠前列腺指数、白细胞和卵磷脂小体数量、乳酸脱氢酶5与乳酸脱氢酶1的比值(LDH5/LDH1)以及前列腺病理改变,并对前列腺组织内炎细胞、成纤维细胞、腺体数量和腺腔的面积等形态学变化情况进行分析。结果:京尼平苷高、中剂量组、前列康片组与模型组比较,前列腺指数、白细胞数和LDH5/LDH1均明显下降,而卵磷脂小体数量显著上升(P<0.01或P<0.05);京尼平苷高剂量组及前列康片组与模型组相比,间质中炎细胞数、成纤维细胞数均显著降低,腺体数量与腺腔面积明显升高(P<0.05或P<0.01)。结论:高、中剂量京尼平苷可减轻炎细胞浸润、抑制纤维组织增生和恢复前列腺分泌功能,对大鼠慢性前列腺炎具有较好的治疗作用。

Objective： To study the effect of geniposide on treating experimental CP rats.Method： The animal model of CP was made with rats by injecting hemorrhoid injection.Rats in experiment group were randomly devided into model group,Qianliekang tablets group（2 g·kg-1）and geniposide high,middle,low dose groups（20,10,5 mg·kg-1）.Subsequently,the state of all rats,prostate index,WBC and lecithine corpuscle,LDH5/LDH1,and prostatic histopathological changes were observed.Count of total cellular score（TCS） and quantitation of inflammatory cell,fibroblasts,glandular organ,calculation of glandular cavity area,and their changes of morphology were analyzed.Result： Compared with model group,the prostate index,WBC and LDH5/LDH1 of the rats in Qianliekang tablets group,high dose geniposide group and middle dose geniposide group were significantly decreased,while the quantities of lecithine corpuscle were remarkably increased（P0.01 or P0.05）.Compared with model group,the number of inflammatory cells and fibroblasts in Qianliekang tablets group,high dose geniposide group were decreased,and the quantity of glandular organ and area of glandular cavity in these groups were increased（P0.05 or P0.01）.Conclusion： Geniposide of high and middle dose can reduce leucocytes infiltration,restrain the hyperplasia of fibrous tissue,and recover the secretion function of prostate.It show that geniposide is significantly potential to cure rats which are exposed to chronic prostatitis.