2型糖尿病微量白蛋白尿与颈总动脉内膜中层厚度的相关性研究

Relationship between microalbuminuria and carotid intima mediu thickness in type 2 diabetes mellitus

目的研究2型糖尿病微量白蛋白尿与颈总动脉内膜中层厚度（CIMT）的关系。方法选取2型糖尿病150例,根据尿微量白蛋白排泄率（UAER）分为DM-A组52例（UAER〈20μg/min）,DM-B组54例（UAER在20-200μg/min之间）,DM-C组54例（UAER〉200μg/min）;并设立正常对照组20例,测定其颈总动脉内膜中层厚度,观察尿微量白蛋白与颈总动脉内膜中层厚度的关系。结果糖尿病组CIMT明显高于正常对照组,糖尿病各亚组中,DM-B组及DM-C组的CIMT均显著高于DM-A组（P〈0.01）,DM-C组的CIMT显著高于DM-B组（P〈0.01）。结论尿微量白蛋白排泄率越高,颈总动脉内中膜中层厚度增加。

Objective To investigate the relationship between microalbuminuria and carotid intima mediu thickness in type 2 diabetes mellitus.Methods One hundred and fifty patients with type 2 diabetes mellitus,were divided into group DM-A whose urinary albumin excretion rate（UAER） were normal（UAER20 μg/min）,and group DM-B who were with microalbuminuria（UAER between 20-200 μg/min）,and group DM-C who were with macroalbuminuria（UAER200 μg/min）.There were 20 controls who were age-matched and sex-matched.The carotid intima mediu thickness were measured to investigate the relationship between microalbuminuria and carotid intima mediu thickness（CIMT）.Results The CIMT were greater in diabetic patients than that in control subjects（P0.01）,and greater in groups DM-B and DM-C than that in group DM-A（P0.01）.CIMT was greater in group DM-C than that in group DM-B（P0.01）.Conclusion The more albuminuria is,the greater CIMT is.