伴有中央颞区棘波的良性癫对儿童智力的影响

Influence of Benign Epilepsy of Childhood with Centrotemporal Spikes on Intelligence Quotient

目的探讨伴有中央颞区棘波的良性癫(BECTS)及脑电图癫样放电对儿童智力的影响。方法对42例BECTS患儿(BECTS组)应用中国韦氏儿童智力量表进行智力测定,与21例年龄、性别、受教育情况及家庭背景相匹配的呼吸道感染儿童(对照组)进行比较;并将其临床资料(包括起病年龄、病程、发作频率及脑电图的放电频率等)按不同等级分类后进行相关性分析,使用SPSS13.0软件观察各种因素对BECTS患儿智力的影响。结果BECTS组患儿各项智商均值均低于对照组,且言语智商和总智商均值和对照组比较差异均有统计学意义(Pa<0.05);BECTS组病程与言语智商、总智商具有相关性(Pa<0.05);BECTS患儿清醒期脑电图的异常放电频率与言语智商、总智商具有相关性(Pa<0.05),而其思睡期及非快动眼睡眠期无相关性。结论BECTS患儿与对照儿童相比,智力水平下降,且言语智商受损更为明显。病程和清醒期脑电图异常放电频率影响BECTS患儿的智力水平,尤其是对言语智商的影响更为显著。

Objective To explore the effect of benign epilepsy of childhood with centrotemporal spikes（BECTS） and epileptiform discharge of electroencephalogram（EEG）on intelligence quotient （IQ）.Methods IQ of the 42 children with BECTS（BECTS group） were examined by Wechsler intelligence scale for children （WISC） and compared with 21 controls children（control group） matched for age,schooling,gender and family background;their clinical data （including age-at-onset,course of epilepsy,frequency of seizures,epileptiform frequency of EEG） were analyzed by different degrees to observe the influence of various factors on IQ of the children with BECTS.SPSS 13.0 software was used to analyze the data.Results Each item of IQ of 42 children with BECTS were lower than those of the control group,but the mean scores of language IQ and total IQ were significantly lower than those of the controls′（Pa0.05）.The course of BECTS was correlated with language IQ and total IQ（Pa0.05）.Only epileptiform frequency of EEG when awake was correlated with language IQ and total IQ（Pa0.05）.There was no correlation between epileptiform frequency of EEG and IQ when drowsy and sleeping.Conclusions Compared with control children,IQ of the children with BECTS decreases and the language IQ is impaired remarkably.The course of epilepsy and epileptiform frequency of EEG when awake influence significantly the intelligence level,especially language intelligence of the children with BECTS.