雾化吸入液中氯化钠浓度对气管插管患者排痰效果的影响

The effect on expectoration by concentration of sodium chloride inhalation solution for patients with endotracheal intubation

目的探讨三种不同浓度的高渗盐水雾化对肝移植气管插管患者术后排痰量、痰标本的合格率和痰液粘稠度的影响,找出最适宜的高渗盐水雾化浓度,为肝移植患者有效排痰和辅助诊断肺感染提供一条新途径。方法选取肝移植术后气管插管患者120例,随机分为干预组三组各30名和对照组30名。干预组三组分别雾化吸入浓度为3%、5%、7%的高渗盐水6ml,对照组雾化吸入浓度为0.45%的低渗盐水6ml,吸入时间均为20min,记录雾化后四组患者的痰量、痰液粘稠度及痰标本的合格率。结果四组患者痰量、痰液粘稠度及痰标本的合格率差异有显著意义(P<0.05)。结论肝移植术后气管插管患者适宜的高渗盐水雾化浓度为5%。

Objective To investigate the effects of three different concentrations of hypertonic saline aerosol on expectoration volume, the passing rate of sputum samples and sputum viscosity of patients with endotracheal intubation after liver transplantation, and to find a new way dedicated to diagnosis of pulmonary infection for those patients. Method 120 patients undergoing liver transplantation surgery with endotraeheal intubation were randomly divided into four groups. There were three groups by concentration of inhaled hypertonic saline, such as inhaled 3 %, 5% and 70/40 hypertonic saline 6mL respectively, as intervention group, and delivered by an ultrasonic nebulizer device for 20 minutes while 30 cases on control group was inhaled 0.45% saline in same way, the expectoration volume, the passing rate of sputum samples and sputum viscosity were recorded. Result There was significantly difference in expectoration volume, passing rate of sputum samples and sputum viscosity between intervention and control group（P〈0.05）. Conclusion It＇s concluded that the appropriate concentration of hypertonic saline aerosol for patients after liver transplantation is 5 %.