摘要
合成了5种Salen Mn(Ⅱ)及2种Salen Eu(Ⅲ)配合物。以NBT/核黄素(VB2)/蛋氨酸为O2.-的产生、检测体系,对上述配合物进行了抗O2.-活性研究,发现Mn(Ⅱ)配合物对O2.-均具有较为明显的清除活性。用荧光检测法对上述配合物与ct-DNA的作用进行了研究,结果显示其均能与DNA产生结合作用,提示具有潜在抗癌活性。
Five kinds of Salen Mn（Ⅱ） and two kinds of Eu（Ⅲ） complexes were synthesized. Under the system of NBT/L-methionine, which creats and detects O2^·-, the complexes of antioxidant activity were studied, and the conclusion revealed that all Mn（Ⅱ） complexes have obvious antioxidant activity. The fluorescence study indicated that all the Salen metal complexes could bind with DNA, which shows their potential anticancer activity.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2010年第5期1386-1390,共5页
Spectroscopy and Spectral Analysis
基金
supported by the National Natural Science Foundation of China(20972015)
the Natural Science Foundation of Beijing(Grant2082016)
a joint project of Beijing Municipal Education Commission(China)
